An adverse drug reaction (abbreviated ADR) is an expression that describes harm associated with the use of given medications at a normal dose. The meaning of this expression differs from the meaning of "side effect", as this last expression might also imply that the effects can be beneficial. The study of ADRs is the concern of the field known as pharmacovigilance.

Classification

ADRs may be classified by e.g. cause and severity.

Cause

  • Type A: Augmented pharmacologic effects - dose dependent and predictable
a.Intolerance
b.side effects
  • Type B: Bizarre effects (or idiosyncratic) - dose independent and unpredictable
  • Type C: Chronic effects
  • Type D: Delayed effects
  • Type E: End-of-treatment effects
  • Type F: Failure of therapy

Types A and B were proposed in the 1970s, and the other types were proposed subsequently when the first two proved insufficient to classify ADRs.

From Wikipedia under the GNU Free Documentation License
Fri Sep 3 02:40:57 2010

Has anyone had a bad adverse reaction from a drug?
Q. I'm talking about perscription drugs, given by a doctor. I had a terribly hard time walking after being overdosed levaquin by a doctor (for a very long time). It's been more than a year and I am still very weak (It's even hard to open the door). I also still get pre-seizures from it. I'm wondering if anyone ELSE has had a severe reaction to a perscription drug, too. If so, how long did it last?
Asked by friendlygal - Thu Mar 26 13:48:02 2009 - - 4 Answers - 0 Comments

A. I had an anaphylaxis reaction to Levaquin. Nothing like what you've experienced, but a terrible reaction still. It happened within minutes of taking it one time (for an ear infection). My face starting swelling, and then my throat starting swelling shut making it very hard to breathe. My husband took me to the ER right away & they started an iv that fixed everything. I don't have any problems now, but I know to stay away from that drug. I read online after my allergic reaction that people have had the same reaction you've had to Levaquin. I'm sure it isn't extremely common, but had I known it happens as much as it does, I don't know whether I would have risked taking it. I heard on a call-in show the other day that lots of people want… [cont.]
Answered by Dirty Sanchez - Thu Mar 26 13:57:03 2009

how does isoniazid causes hematologic dysfunction?
Q. as per drug information about isoniazid, some of its adverse drug reactions is agranulocytosis, anemia, thrombocytopenia. how can it cause these hematologic dysfunctions?
Asked by Ma. Theresa D - Mon Nov 17 08:33:18 2008 - - 1 Answers - 0 Comments

A. Generic name: isoniazid ( INH) brand name(S): Niazid INH; Isonicotinic Acid Hydrazide This medication is used to prevent and treat tuberculosis. Rarely, this medication has caused severe (sometimes fatal) liver problems (e.g.,fatal hepatitis) As with all drugs; it can cause enlargement of the liver or liver dysfunctions/problems. . This drug can cause hepatoxicity. One of the main functions of the liver is clearance of waste products, drugs, and toxins. . In addition, the liver metabolizes most hormones and ingested drugs to either more or less active products. Nearly all drugs are modified or degraded in the liver. In particular, oral drugs are absorbed by the gut and transported via the portal circulation to the liver. In… [cont.]
Answered by rosieC - Mon Nov 17 09:29:24 2008

Betaseron adverse reaction?
Q. Has anyone that has taken Betaseron had any severe side effects like body swelling, severe weakness and paralysis? Do you know anyone that has had these effects with the drug? Joker, you know someone who has had ill-effects?
Asked by Veronica - Fri Apr 17 16:46:32 2009 - - 1 Answers - 0 Comments

A. Yes. Stop taking it and see your neurologist. ^^
Answered by Mr. LOL - Sun Apr 19 13:16:07 2009

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Figure 8

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Adverse drug reaction rate mean = 7 45 Standard deviation = 9

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